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Synthesis and antibacterial activity of 6-difluoromethoxy-7-piperazinyl-3-quinolinecarboxylic acid derivatives

✍ Scribed by R. Krishnan; S. A. Lang Jr.

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
274 KB
Volume
77
Category
Article
ISSN
0022-3549

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Synthesis of carbon-14-labelled antibacterial agent. Synthesis of 1-ethyl- [1-14C]-6-fluoro-1, 4-dihydro-4-oxo-7- (1-piperazinyl)-3-quinolinecarboxylic acid (14C-AM-715)
✍ Y. Nagatsu; T. Irikura πŸ“‚ Article πŸ“… 1981 πŸ› John Wiley and Sons 🌐 French βš– 236 KB

## Abstract 1‐Ethyl‐6‐fluoro‐1,4‐dihydro‐4‐oxo‐7‐(1‐piperazinyl)‐ 3‐quinolinecarboxylic acid (__I__, AM‐715), a new potent antibacterial agent, was labelled with carbon‐14 at the C‐1 position of the N‐ethyl group for metabolic studies. The synthesis was achieved according to two reaction routes. Th