✦ LIBER ✦

Synthesis and antibacterial activity of 2α-functionalized 1β-methylcarbapenems related to KR-21012

✍ Scribed by Hyun J. Kwak; Do K. Pyun; Jae H. Kim; Eun J. Kim; Hee J. Jeong; Bong J. Kim; Cheol H. Lee

Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 148 KB
Volume: 10
Category: Article
ISSN: 0960-894X
DOI: 10.1016/s0960-894x(99)00692-7

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✦ Synopsis

AbstractÐThe 2a-functionalized 1b-methylcarbapenems 3 were synthesized from the 2-formyl 1b-methylcarbapenem intermediate 5. The best compound in the series of 2a-(hydroxy)alkylcarbapenems, KR-21012, displayed well balanced in vitro and in vivo activity as a parent compound of oral carbapenem.

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