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Synthesis and anti-tetrabenazine activity of c-3 analogues of dimethyl-2-phenylmorpholines

โœ Scribed by G. Evan Boswell; David L. Musso; James L. Kelley; Francis E. Soroko; Barret R. Cooper


Book ID
112131421
Publisher
Journal of Heterocyclic Chemistry
Year
1996
Tongue
English
Weight
594 KB
Volume
33
Category
Article
ISSN
0022-152X

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Synthesis, stereochemistry and anti-tetr
โœ G. Evan Boswell; David L. Musso; Ann O. Davis; James L. Kelley; Francis E. Sorok ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Journal of Heterocyclic Chemistry ๐ŸŒ English โš– 669 KB

A series of bicyclo analogues of several 2-phenylmorpholines were synthesized and tested for anti-tetrabenazine activity in mice. Most of the target compounds were prepared by reaction of 2-bromopropiophenone (22) with the appropriate amino alcohol to form 2-phenylmorpholinols. Reduction of the 2-ph