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ChemInform Abstract: Synthesis and Antitetrabenazine Activity of C-3 Analogues of Dimethyl- 2-phenylmorpholines.

โœ Scribed by G. E. BOSWELL; D. L. MUSSO; J. L. KELLEY; F. E. SOROKO; B. R. COOPER


Book ID
112035053
Publisher
John Wiley and Sons
Year
2010
Weight
31 KB
Volume
27
Category
Article
ISSN
0931-7597

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Synthesis, stereochemistry and anti-tetr
โœ G. Evan Boswell; David L. Musso; Ann O. Davis; James L. Kelley; Francis E. Sorok ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Journal of Heterocyclic Chemistry ๐ŸŒ English โš– 669 KB

A series of bicyclo analogues of several 2-phenylmorpholines were synthesized and tested for anti-tetrabenazine activity in mice. Most of the target compounds were prepared by reaction of 2-bromopropiophenone (22) with the appropriate amino alcohol to form 2-phenylmorpholinols. Reduction of the 2-ph