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Synthesis and anti-HIV activity of some novel diaryl phosphate derivatives of AZT

โœ Scribed by Christopher McGuigan; Michael Davies; Ranjith Pathirana; Naheed Mahmood; Alan J. Hay


Book ID
118393380
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
454 KB
Volume
24
Category
Article
ISSN
0166-3542

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Synthesis, Anti-HIV Activity, and Stabil
โœ D. Egron; A.A. Arzumanov; N.B. Dyatkina; A.-M. Aubertin; J.-L. Imbach; G. Gossel ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 134 KB

The synthesis, in vitro anti-HIV activity and stability studies of the 5ะˆ-fluorophosphate derivative of 3ะˆ-azido-3ะˆ-deoxythymidine (AZT) are reported. The results support the hypothesis that this phosphorylated entity exerts its biological effect via the delivery of the corresponding 5ะˆ-mononucleoti