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Synthesis and anti-HIV activity evaluation of novelN′-arylidene-2-[1-(naphthalen-1-yl)-1H-tetrazol-5-ylthio]acetohydrazides

✍ Scribed by Peng Zhan; Hongbing Liu; Xinyong Liu; Yan Wang; Christophe Pannecouque; Myriam Witvrouw; Erik De Clercq


Publisher
Springer-Verlag
Year
2009
Tongue
English
Weight
354 KB
Volume
19
Category
Article
ISSN
1054-2523

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Aryloxy tetrazoles with axial chirality:
✍ Hossein A. Dabbagh; Alireza Najafi Chermahini; Abbas Teimouri 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 95 KB

## 5-(1-(2-Methoxynaphthalen-1-yl)naph- thalen-2-yloxy)-1H-tetrazole as the first aryloxy tetrazole with axial chirality was synthesized. Partial resolution was achieved using (S)-proline and methylbenzylamine as the resolving agents. Best results were obtained using methylbenzylamine with 75-85%