Aryloxy tetrazoles with axial chirality: Synthesis and partial resolution of 5-(1-(2-methoxynaphthalen-1-yl)naphthalen-2-yloxy)-1H-tetrazole

✍ Scribed by Hossein A. Dabbagh; Alireza Najafi Chermahini; Abbas Teimouri

• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 95 KB
• Volume: 17
• Category: Article
• ISSN: 1042-7163
• DOI: 10.1002/hc.20241

✦ Synopsis

5-(1-(2-Methoxynaphthalen-1-yl)naph-

thalen-2-yloxy)-1H-tetrazole as the first aryloxy tetrazole with axial chirality was synthesized. Partial resolution was achieved using (S)-proline and methylbenzylamine as the resolving agents. Best results were obtained using methylbenzylamine with 75-85% ee.