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Synthesis and anti-filarial activity of 6-(3-aminophenyl)-2,3,5,6-tetrahydroimidazol[2,1-b]thiazole derivatives

✍ Scribed by JCW Comley; JP Court; WE Gutteridge; AT Hudson; DC Jenkins; DD Miller; RH Nicol; AW Randall; JN Stables; R Thornton

Publisher
Elsevier Science
Year
1992
Tongue
French
Weight
808 KB
Volume
27
Category
Article
ISSN
0223-5234

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High throughput synthesis of 2,3,6-trisu
High throughput synthesis of 2,3,6-trisubstituted-5,6-dihydroimidazo[2,1-b]thiazole derivatives
✍ Yangmei Li; Marc Giulianotti; Richard A. Houghten πŸ“‚ Article πŸ“… 2011 πŸ› Elsevier Science 🌐 French βš– 259 KB

A facile approach to the synthesis of 2,3,6-trisubstituted-5,6-dihydroimidazo[2,1-b]thiazole was reported. A resin bound cyclic thiourea was formed by the treatment of a resin bound diamine with 1,1'-thiocarbonyldiimidazole, and then reacted with a Ξ±-haloketone to generate a resin bound isothiourea.