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Synthesis of 2-acetyl-5-(1,2,3,4,5,6-hexahydroxyhexyl)thiazoles

✍ Scribed by Alison T. Ung; Stephen G. Pyne; George R. Jeoffreys; Brian W. Skelton; Allan H. White


Publisher
Springer Vienna
Year
2011
Tongue
English
Weight
513 KB
Volume
142
Category
Article
ISSN
0026-9247

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## Abstract The synthesis of two diastereomers of the title compound involves the coupling of 5‐lithiated 2‐(1,1‐dimethoxyethyl)thiazole (VI) with a Weinreb amide (V) derived from gluconolacetone, followed by asymmetric reduction of the ketone functionality.

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