✦ LIBER ✦

Synthesis and Anti-Candida Potential of Certain Novel 1-[(3-Substituted-3-phenyl)propyl]-1H-imidazoles

✍ Scribed by Mohamed Nabil Aboul-Enein; Aida Abd El-Sattar El-Azzouny; Mohamed Ibrahim Attia; Ola Ahmed Saleh; Amany Lotfy Kansoh

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 150 KB
Volume: 344
Category: Article
ISSN: 0365-6233
DOI: 10.1002/ardp.201000224

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The synthesis and anti‐Candida activity of 1‐[(3‐aroyloxy‐3‐phenyl)propyl]‐1__H__‐imidazoles 5a–f and 1‐[(3‐alkyl/aralkyl/phenyl‐3‐phenyl)propan‐3‐ol]‐1__H__‐imidazoles 5g–j are reported. The influence of the ester formation and different substitutions on the anti‐Candida activity of the alcohol 4 was investigated. Among the newly developed bioactive chemical entities, compounds 5b and 5c displayed minimum inhibitory concentrations (MICs) against Candida albicans and Candida pseudotropicales comparable to that of tioconazole and more potent than miconazole.

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