Synthesis and anti-cancer activity of chalcone linked imidazolones

✍ Scribed by Ahmed Kamal; G. Ramakrishna; P. Raju; A. Viswanath; M. Janaki Ramaiah; G. Balakishan; Manika Pal-Bhadra

• Book ID: 104004569
• Publisher: Elsevier Science
• Year: 2010
• Tongue: English
• Weight: 584 KB
• Volume: 20
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/j.bmcl.2010.06.097

✦ Synopsis

A series of novel chalcone linked imidazolones were prepared and evaluated for their anti-cancer activity against a panel of 53 human tumour cell lines derived from nine different cancer types: leukemia, lung, colon, CNS, melanoma, ovarian, renal, prostate and breast. Some of these hybrids (6, 7 and 8) showed good anti-cancer activity with GI 50 values ranging from 1.26 to 13.9 lM. When breast carcinoma cells (MCF-7) were treated with 10 lM concentration of compounds TMAC, CA-4, 6 and 8 cell cycle arrest was observed in G2/M phase. Surprisingly, the increased concentration of the same compound to 30 lM caused accumulation of cells in G0/G1 phase of the cell cycle.