A series of novel chalcone linked imidazolones were prepared and evaluated for their anti-cancer activity against a panel of 53 human tumour cell lines derived from nine different cancer types: leukemia, lung, colon, CNS, melanoma, ovarian, renal, prostate and breast. Some of these hybrids (6, 7 and
โฆ LIBER โฆ
Anti-breast cancer activity of heteroaryl chalcone derivatives
โ Scribed by V.Raja. Solomon; Hoyun Lee
- Book ID
- 116314435
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 367 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0753-3322
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## Abstract Three series of heteroaryl chalcones, (E)-1-(2-pyridyl)-3-(X)prop-2-en-1-one (Ia-Ic), (E)-1-(2-thienyl)-3-(X)prop-2-en-1-one (IIa-IIc), and (E)-1-(2-furyl)-3-(X)prop-2-en-1-one (IIIa-IIIc), where X = 2,4,5-trimethoxyphenyl (for series a), X = 2,4,6-trimethoxyphenyl (for series b), and X