Synthesis and anthelmintic activity of pyrimidinoperimidines
✍ Scribed by S. K. Drusvyatskaya; B. V. Lopatin; É. V. Pereverzeva; A. F. Bekhli
- Book ID
- 112400718
- Publisher
- Springer
- Year
- 1983
- Tongue
- English
- Weight
- 318 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0091-150X
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📜 SIMILAR VOLUMES
A mono-proline analogue of the potent anthelmintic cyclooctadepsipeptide PF1022A has been synthesized. NMR studies in combination with molecular dynamics simulations demonstrate that the conürmation of this analogue is both rigidiüed and distorted compared with the asymmetric conformation of PF1022A
## Abstract The preparation and anthelmintic properties of isopelletierine and four side‐chain homologues are described. The compounds were prepared from Δ~1~‐piperideine and 3‐oxo‐acids at pH 4‐5. pK′~a−~ and Rf‐values were determined. Anthelmintic activity as tested __in vitro__ on the liver fluk