Synthesis and anthelmintic activity of isopelletierine and a series of side-chain homologues

✍ Scribed by J. van Noordwijk; J. J. Mellink; B. J. Visser; J. H. Wisse

• Book ID: 104586662
• Publisher: Elsevier Science
• Year: 2010
• Tongue: English
• Weight: 405 KB
• Volume: 82
• Category: Article
• ISSN: 0165-0513
• DOI: 10.1002/recl.19630820804

✦ Synopsis

Abstract

The preparation and anthelmintic properties of isopelletierine and four side‐chain homologues are described. The compounds were prepared from Δ~1~‐piperideine and 3‐oxo‐acids at pH 4‐5. pK′~a−~ and Rf‐values were determined. Anthelmintic activity as tested in vitro on the liver fluke, by three methods, was highest for 1‐(2′‐piperidyl)butanone‐2. The differences in anthelmintic properties of the compounds are discussed.