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Synthesis and analytical properties of (S)-(+)-2-methoxy-2-(9-phenanthryl)propionic acid

✍ Scribed by Akio Ichikawa; Hiroshi Ono; Nobuyuki Harada

Book ID
104359875
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
211 KB
Volume
14
Category
Article
ISSN
0957-4166

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✦ Synopsis

2-Methoxy-2-(9-phenanthryl)propionic acid was synthesized as a novel chiral resolving agent. The absolute configuration of (+)-2-methoxy-2-(9-phenanthryl)propionic acid was determined to be S by using X-ray structural analysis of the (1R,2S,5R)-menthyl ester. In the crystal, the methoxyl and carbonyl groups of the ester are in a syn-periplanar position. The syn-periplanar conformations of (1R,2S,5R)-menthyl esters were also observed by the NMR analyses in CDCl 3 . The utility of (S)-(+)-2-methoxy-2-(9-phenanthryl)propionic acid was exemplified by the resolution of (±)-3-octanol.

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✍ Ronald J. Parry; Rajesh Turakhia 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 French ⚖ 365 KB 👁 1 views

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