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Synthesis and analysis of a macrocyclic triproline-derived template containing a local conformational constraint

โœ Scribed by D.S. Kemp; Jeffrey H. Rothman

Publisher
Elsevier Science
Year
1995
Tongue
French
Weight
199 KB
Volume
36
Category
Article
ISSN
0040-4039

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## Abstract The synthesis and conformational analysis of model pentapeptides with the sequence Zโ€Leuโ€Aibโ€Xaaโ€Glnโ€Valol is described. These peptides contain two 2,2โ€disubstituted glycines (__ฮฑ__,__ฮฑ__โ€disubstituted __ฮฑ__โ€amino acids), __i.e.__, Aib (aminoisobutyric acid), and a series of unsymmetric