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Synthesis and analysis of 2-[211At]-l-phenylalanine and 4-[211At]-l-phenylalanine and their uptake in human glioma cell cultures in-vitro

✍ Scribed by Geerd J. Meyer; Almut Walte; Siva R. Sriyapureddy; Michaela Grote; Doris Krull; Zekiye Korkmaz; Wolfram H. Knapp


Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
444 KB
Volume
68
Category
Article
ISSN
0969-8043

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The four stereoisomers of the parent keto acid of the oximino drug ximoprofen have been prepared in high enantiomeric purity. The stereochemistry in the propionic acid chain was established by the combination of Sharpless epoxidation followed by stereoselective hydrogenolysis of the benzylic carbon-