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Synthesis and .alpha.2-adrenoceptor antagonist activity of some disulfonamidobenzoquinolizines

โœ Scribed by Ward, Terence J.; Warrellow, Graham J.; Stirrup, John A.; Lattimer, Norman; Rhodes, Keith F.

Book ID
127024150
Publisher
American Chemical Society
Year
1989
Tongue
English
Weight
449 KB
Volume
32
Category
Article
ISSN
0022-2623

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Synthesis of a selective alpha-2A adreno
Synthesis of a selective alpha-2A adrenoceptor antagonist, BRL 48962, and its characterization at cloned human alpha-adrenoceptors
โœ Lee J. Beeley; John M. Berge; Helen Chapman; Paul Hieble; John Kelly; Diane P. N ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 493 KB

The chiral synthesis of the potent and selective alpha-2A antagonist, BRL 48962, is described. Evaluation of BRL 48962 at cloned human alpha-adrenoceptors indicates that this antagonist has a selectivity in the order of 30-fold for the alpha-2A subtype.