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Synthesis and activity of a potent α-glucosidase inhibitor, (1R, 6R, 8S)-cis-1,6-dihydroxypyrrolizidine, and its isomer

✍ Scribed by Kyeong-Eun Jung; Yong-Koo Kang; Dong Jin Kim; Sang Woo Park

Book ID
105672422
Publisher
Springer
Year
1997
Tongue
English
Weight
457 KB
Volume
20
Category
Article
ISSN
0253-6269

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✍ Robert Łysek; Catherine Schütz; Pierre Vogel 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 German ⚖ 341 KB

## Abstract (−)‐ and (+)‐Conduramine B‐1 ((−)‐ and (+)‐5, resp.) have been derived from (+)‐ and (−)‐7‐oxabicyclo[2.2.1]hept‐5‐en‐2‐one (‘naked sugars’ of the first generation). Although (−)‐5 imitates the structure of __β__‐glucosides, it does not inhibit __β__‐glucosidases but inhibits __α__‐mann