Synthesis of (r)- and (s)-1-formyl-6,7,8,9-tetrahydro- N,N-(dipropyl)-3H-benz[e]indol-8-amines: Potent and orally active 5-ht1a receptor agonists
✍ Scribed by Chiu-Hong Lin; Michael D. Ennis; Robert L. Hoffman; Gillian Phillips; Susanne R. Haadsma-Svensson; Nabil B. Ghazal; Connie G. Chidester
- Book ID
- 112130852
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 1994
- Tongue
- English
- Weight
- 769 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0022-152X
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract The title compounds were synthesised in 7 steps from 1,7‐dihydroxynaphthalene as follows: 1,7‐dihydroxynaphthalene was methylated and subjected to a Birch reduction to yield 8‐methoxy‐2‐tetralone. Reductive amination with sodium cyanoboro[^3^H]hydride and n‐propylamine gave 8‐methoxy‐2‐
## Abstract The now corrected X‐ray structure of (2__R__)‐bornane‐10,2‐sultam ((−)‐**1a**), as well as that of its already published __N__‐crotonoyl derivative (−)‐**1d**, were compared with those of the newly synthesized (2__R__)‐fenchane‐8,2‐sultam ((+)‐**5a**), as well as its __N__‐crotonoyl der