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Synthesis and absolute configuration of three natural ent-halimanolides with biological activity

✍ Scribed by I.S Marcos; A.B Pedrero; M.J Sexmero; D Diez; P Basabe; F.A Hernández; J.G Urones

Book ID
104252646
Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
109 KB
Volume
44
Category
Article
ISSN
0040-4039

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✦ Synopsis

The first three natural ent-halimanolides known until now have been synthesized from ent-halimic acid. Their structure have been confirmed as well as their absolute configurations established. Bestmann methodology has been used for the synthesis of butenolides and for the g-hydroxybutenolides synthesis the Boukouvalas method has been employed. Biological testing has been carried out on these compounds.

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✍ Goverdhan Mehta; Kabirul Islam 📂 Article 📅 2003 🏛 Elsevier Science 🌐 French ⚖ 208 KB

Following our recent total synthesis of the biologically potent natural products otteliones A and B in racemic form, we have now accomplished the total synthesis of both the enantiomers of otteliones A and B through an enantiodivergent strategy emanating from the readily available Diels-Alder adduct