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Synthesis and absolute configuration of the isomers of homoiscitric acid (1-hydroxy-1,2,4-butanetricarboxylic acid) and the stereochemistry of lysine biosynthesis

โœ Scribed by Chilina, Karen; Thomas, Ursula; Tucci, Anthony F.; McMichael, K. D.; Stevens, Carl M.


Book ID
127176358
Publisher
American Chemical Society
Year
1969
Tongue
English
Weight
974 KB
Volume
8
Category
Article
ISSN
0006-2960

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The compound [2-(1-diethylaminopropyl)] 1-hydroxy-1,1ะˆ-bicyclohexyl-2-carboxylate 1 is a muscarinic antagonist characterized by the presence of three chiral atoms and eight possible stereoisomers. The binding affinities to the five cloned m 1 -m 5 muscarinic receptors of the stereoisomers of 1 were