## Abstract Sevoflurane was synthesized with deuterium substituents on the fluoromethoxy carbon. This was performed by a twoβstep reaction process that yielded deuterated sevoflurane of high purity.
Synthesis and 1H-NMR spectra of 1,1-dideutero- and 2,2-dideutero-4-phenylbutane
β Scribed by R. P. A. Sneeden; H. H. Zeiss
- Publisher
- John Wiley and Sons
- Year
- 1969
- Tongue
- French
- Weight
- 461 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0022-2135
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π SIMILAR VOLUMES
A new total synthesis of a protoporphyrin IX derivative in which the Ξ±-methylene protons of the 13,17-(2-methoxycarbonylethyl) substituents are regioselectively deuterated is described. The deuterated porphyrin was obtained using the oxidative cyclization of an a,c-biladiene dihydrobromide.
The 17O, 13C and 1H NMR spectra of a number of 1,2-dialkoxyethenes R1OCHxCHOR2 were recorded. The O atoms, in particular those of the E forms, are strongly shielded relative to the 17O nuclei of the corresponding alkyl vinyl ethers Moreover, in compounds of the type ROCHxCHOMe, the di β er-ROCHxCH 2