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Syntheses, Structures, and Enzymic Evaluations of Conformationally Constrained, Analog Inhibitors of Carnitine Acetyltransferase: (2R,6R)-, (2S,6S)-, (2R,6S)-, and (2S,6R)-6-(Carboxylatomethyl)-2-(hydroxymethyl)-2,4,4-trimethylmorpholinium

โœ Scribed by Sun, Guobin; Savle, Prashant S.; Gandour, Richard D.; Bhaird, Noirin Nic a; Ramsay, Rona R.; Fronczek, Frank R.


Book ID
120160705
Publisher
American Chemical Society
Year
1995
Tongue
English
Weight
973 KB
Volume
60
Category
Article
ISSN
0022-3263

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Asymmetric synthesis of (2R,6R) and (2S,
โœ John W. Mickelson; E.Jon Jacobsen ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 179 KB

The title compounds were prepared via two efficient routes. The first sequence utilized a diastereospecific triflate alkylation in the key bond forming step while the second method relied on a novel intramolecular Mitsunobu reaction to set the required stereochemistry. Many pharmaceutical agents co