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ChemInform Abstract: Asymmetric Synthesis of (2R,6R) and (2S,6S)-2,6-Dimethylpiperazine.

โœ Scribed by J. W. MICKELSON; E. J. JACOBSEN


Book ID
112023102
Publisher
John Wiley and Sons
Year
2010
Weight
33 KB
Volume
26
Category
Article
ISSN
0931-7597

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Asymmetric synthesis of (2R,6R) and (2S,
โœ John W. Mickelson; E.Jon Jacobsen ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 179 KB

The title compounds were prepared via two efficient routes. The first sequence utilized a diastereospecific triflate alkylation in the key bond forming step while the second method relied on a novel intramolecular Mitsunobu reaction to set the required stereochemistry. Many pharmaceutical agents co