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ChemInform Abstract: Asymmetric Synthesis of (-)-(2R,6R)-2,6-Dimethylmorpholine

โœ Scribed by E. LICANDRO; S. MAIORANA; A. PAPAGNI; M. PRYCE; A. ZANOTTI GEROSA; S. RIVA

Book ID
112024763
Publisher
John Wiley and Sons
Year
2010
Weight
28 KB
Volume
27
Category
Article
ISSN
0931-7597

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โœ John W. Mickelson; E.Jon Jacobsen ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 179 KB

The title compounds were prepared via two efficient routes. The first sequence utilized a diastereospecific triflate alkylation in the key bond forming step while the second method relied on a novel intramolecular Mitsunobu reaction to set the required stereochemistry. Many pharmaceutical agents co