Syntheses of two isotopically labeled CB1 receptor antagonists
β Scribed by Boris A. Czeskis
- Book ID
- 112132916
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- French
- Weight
- 890 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0022-2135
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## Syntheses of [I 3C ] and [14C]-labelled versions of angiotensin I1 receptor antagonist GR138950X, labelled in the imidazole carboxamide residue, are described. These involved preparation of an iodoimidazole substrate by a novel iododecarboxylation procedure, followed by cyanation with a mixture
## Abstract Syntheses of labelled versions of 5βHT~3~ receptor antagonists, Alosetron and Lurosetron, are described. [^14^C]Alosetron was prepared by routes utilizing either Fischer indolisation of an amidohydrazine or palladiumβmediated cyclisation of an aryl enaminone as key steps. ^2^H and ^13^C