Syntheses of substituted 2-(1-methyl-5-nitro-2-benzimidazolyl)quinolines
✍ Scribed by F. Alimohammadi; S. Abedifard; A. Shafiee
- Book ID
- 112130992
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 1994
- Tongue
- English
- Weight
- 215 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0022-152X
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📜 SIMILAR VOLUMES
## Abstract Reaction of methyllithium with 1‐methy1‐2‐imidazolecarboxaldehyde afforded the corresponding alcohol 2. Oxidation of compound 2 with manganese dioxide gave 2‐acety1‐1‐methylimidazole (3). Using compound 3 and substituted isatins 4, the corresponding quinoline‐4‐carboxylic acids (5) were
## Abstract magnified image Oxidation of metronidazole (**4**) with sodium dichromate yielded the corresponding 2‐(2‐methyl‐5‐nitro‐1__H__‐imidazol‐1‐yl)acetic acid (**5**) which was esterified with 1‐butanol to give butyl 2‐(2‐methyl‐5‐nitro‐1__H__‐imidazol‐1‐yl)acetate (**8**). Reaction of the l
l-Methyl-2-nitro-1K-imidazolea carrying d i f f e r e n t 5-side chain. (iaopropyl, hydroxymethylethyl, ethenyl) have been syn- t h e b e d l a b e l l e d with I 4 C a t C2 of t h e imidazole nucleua.