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Syntheses of some analogs of a possible intermediate formed in the thymidylate synthetase reaction

โœ Scribed by Daniel V. Santi

Book ID
112121647
Publisher
Journal of Heterocyclic Chemistry
Year
1967
Tongue
English
Weight
615 KB
Volume
4
Category
Article
ISSN
0022-152X

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๐Ÿ“œ SIMILAR VOLUMES

Synthesis o an 8-deaza analog of the int
Synthesis o an 8-deaza analog of the intermediate in the thymidylate synthetase reaction
โœ Ananthachari Srinivasan; Arthur D. Broom ๐Ÿ“‚ Article ๐Ÿ“… 1982 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 215 KB

Synthesis of an R-deaza analog of the proposed intermediate in the thymidylate synthetase reaction was accomplished from diethyl R-deazafolic acid and an unambiguous proof of the structure is provided. Thymidylate synthetase catalyzes the conversion of 2'-deoxyuridine-5'-monophosphate (dUMP) to thym