✦ LIBER ✦

Synthesis o an 8-deaza analog of the intermediate in the thymidylate synthetase reaction

✍ Scribed by Ananthachari Srinivasan; Arthur D. Broom

Publisher: Elsevier Science
Year: 1982
Tongue: French
Weight: 215 KB
Volume: 23
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)87125-7

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✦ Synopsis

Synthesis of an R-deaza analog of the proposed intermediate in the thymidylate synthetase reaction was accomplished from diethyl R-deazafolic acid and an unambiguous proof of the structure is provided. Thymidylate synthetase catalyzes the conversion of 2'-deoxyuridine-5'-monophosphate (dUMP) to thymidine-5'-monophosphate (TMP) in the presence of the cofactor N5,N1'-CH2-tetrahydrofolic acid.l

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