Syntheses of sialic acid analogues with acylamino groups at C-4 (N-acyl regioisomers of sialic acids)
✍ Scribed by Xue-Long Sun; Toshitsugu Kai; Hiroaki Takayanagi; Kimio Furuhata
- Book ID
- 108309645
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 828 KB
- Volume
- 298
- Category
- Article
- ISSN
- 0008-6215
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## Abstract 2‐Deoxy‐2‐H~eq~‐__N__‐acetylneuraminic acid (1a) has been shown to be a versatile mimic for sialosyl 2‐α‐glycosides to study the hemagglutinin‐sialic acid interaction. Starting with a 4‐oxo derivative of 2‐deoxy‐2‐H~eq~‐sialic acid, we obtained the 4‐__C__‐methyl~ax~ and 4‐__C__‐methyl~
Chemoenzymatic Synthesis of an N-Acetylneuraminic Acid Analogue Having a Carbamoylmethyl Group at C-4 as an Inhibitor of Sialidase from Influenza Virus. -The synthetic strategy for the preparation of the title analogue (XVI) requires the key intermediate (XII) which is synthesized by the Neu5Ac aldo