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ChemInform Abstract: Chemoenzymatic Synthesis of an N-Acetylneuraminic Acid Analogue Having a Carbamoylmethyl Group at C-4 as an Inhibitor of Sialidase from Influenza Virus.

✍ Scribed by Kiyoshi Ikeda; Fuyuki Kimura; Kimihiko Sano; Yasuo Suzuki; Kazuo Achiwa

Publisher: John Wiley and Sons
Year: 2010
Weight: 38 KB
Volume: 30
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199915240

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✦ Synopsis

Chemoenzymatic Synthesis of an N-Acetylneuraminic Acid Analogue Having a Carbamoylmethyl Group at C-4 as an Inhibitor of Sialidase from Influenza Virus. -The synthetic strategy for the preparation of the title analogue (XVI) requires the key intermediate (XII) which is synthesized by the Neu5Ac aldolase catalyzed aldol reaction of glucose (IV) with sodium pyruvate (V) under Ca-promoted epimerization at 2-position of (IV). Compound (XVI) exhibits weak inhibitory activity. -(IKEDA, KIYOSHI; KIMURA,

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