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Syntheses of proline analogs as potential mechanism-based inhibitors of proline dehydrogenase: 4-methylene-L-, (E)- and (Z)-4-(fluoromethylene)-L-, cis- and trans-5-ethynyl-(.+-.)-, and cis- and trans-5-vinyl-L-proline

✍ Scribed by Manfre, Franco; Kern, Jean Marc; Biellmann, Jean Francois


Book ID
120011905
Publisher
American Chemical Society
Year
1992
Tongue
English
Weight
800 KB
Volume
57
Category
Article
ISSN
0022-3263

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ChemInform Abstract: New Amino Acids Der
✍ J. VAN BETSBRUGGE; W. VAN DEN NEST; P. VERHEYDEN; D. TOURWE πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 38 KB πŸ‘ 2 views

Pyroglutamic acid derivative (I) is proved to be an excellent chiral starting compound for the synthesis of title amino acids (IX), (X), and (V). The syntheses are based on a combination of methods previously used for the preparation of 4-and 5-substituted prolines. These methods are the ring openin