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Syntheses of polycyclic aromatic hydrocarbon-nucleoslde and oligonucleotide adducts specifically alkylated on the amino functions of deoxyguanosine and deoxyadenosine

โœ Scribed by Hongmee Lee; Michael Hinz; John J. Stezowski; Ronald G. Harvey

Publisher
Elsevier Science
Year
1990
Tongue
French
Weight
266 KB
Volume
31
Category
Article
ISSN
0040-4039

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Synthesis and sepamtion of the diastereomeric tram Nz-2'deoxyguanosine edducts of tetrehydrophenanthtae 3,4-epoxide end beauo[a]pyrene 7,8diol9, IO-epoxide (knzylic hydroxyl group end epoxide oxygen tmns), as well es the incaporation of the former into the pentanucleotide TpA#pApT, am described.