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Syntheses of Novel 3-Amino-2(1H)-thioxo-4(3H)-quinazolinones and Evaluation of Their Immunotropic Activity. Part III

✍ Scribed by Wanda Nawrocka; Michal Zimecki

Book ID
102750485
Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
655 KB
Volume
330
Category
Article
ISSN
0365-6233

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✦ Synopsis

Abstract

The synthesis of two series of derivatives containing the quinazolinone‐4 moiety is described. 3‐Amino‐2(1__H__)‐thioxo‐4(3__H__)‐quinazolinone (1) was subjected to reactions with halogenoketones and halogenoaldehydes, leading to the production of the corresponding ketones, aldehydes, Schiff bases, and 6‐oxo‐1,4,5‐thiadiazin[2,3‐b]quinazoline derivatives. Subsequently, 1 was condensed with selected α,β‐unsaturated carbonyl compounds, aldehydes, ketones, acid chlorides, and esters. The compounds were tested for their potential activity in a model of humoral and cellular immune response. The tests showed that the compounds exhibited differential immunotropic activities. Of particular interest is compound 19, exhibiting a strong stimulatory activity with regard to cellular immune response and compound 16 exerting a strong inhibitory action in both types of the immune response.

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