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Syntheses of new pyridonecarboxylic acid derivatives containing 3-,5- or 6-quinolyl substituents at N-1 and their anti-HIV-RT activities

✍ Scribed by Yoon-Seok Oh; Chi-Wbo Lee; Yong-Ho Chung; Sung-June Yoon; Sung- Hye Cho

Publisher: Journal of Heterocyclic Chemistry
Year: 1998
Tongue: English
Weight: 760 KB
Volume: 35
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570350309

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✦ Synopsis

Abstract

A series of new pyridonecarboxylic acid derivatives containing 3‐, 5‐ or 6‐quinolyl substituents at N‐1 were synthesized and their in vitro anti‐HIV‐RT activities were evaluated. Several compounds in this series showed better activity than Atevirdine.

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