✍ Scribed by Yoon-Seok Oh; Sung-Hye Cho
No coin nor oath required. For personal study only.
A series of new pyridonecarboxylic acid derivatives containing 1- or 2-naphthyl substituents at (\mathrm{N}-1) were synthesized and their in vitro anti-HIV-RT activities were evaluated. Several compounds in this series showed better activity than Atevirdine.
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## Abstract A series of new pyridonecarboxylic acid derivatives containing 3‐, 5‐ or 6‐quinolyl substituents at N‐1 were synthesized and their __in vitro__ anti‐HIV‐RT activities were evaluated. Several compounds in this series showed better activity than Atevirdine.
## Abstract The 1‐(5‐fluoro‐2‐pyridyl) or 1‐(3‐fluoro‐4‐pyridyl) group was introduced in the syntheses of new pyridonecarboxylic acid antibacterial agents. 1‐(5‐Fluoro‐2‐pyridyl)‐6‐fluoro‐1,4‐dihydro‐7‐(4‐methyl‐1‐piperazinyl)‐4‐oxoquinolone‐3‐carboxylic acid 7b (DW‐116) showed a moderate __in vitr
Synthesis, Pharmacokinetics, and Biological Activity of a Series of New Pyridonecarboxylic Acid Antibacterial Agents Bearing a 5-Fluoro-2-pyridyl Group or a 3-Fluoro-4-pyridyl Group at N-1. -A variety of new quinolones bearing fluorinated pyridyl groups at N1 ( cf. (VIII), (IX); 18 examples) are syn