Syntheses of heparin saccharides Stereospecific synthesis of derivatives of 2-amino-2-deoxy-4-O-(α-D-glucopyranuronosyl)-D-glucose
✍ Scribed by Joseph Kiss; Pierre C. Wyss
- Publisher
- Elsevier Science
- Year
- 1972
- Tongue
- French
- Weight
- 169 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
The reaction of 2-amino-2-deoxy-D-glucose hydrochloride with 5,5-dimethyl-2-phenylaminomethylene-1 ,fcyclohexanedione in MeOH in the presence of Et,N afforded 2-deoxy-2-[(4,4-dimethyl-2,6-dioxocyclohexylidenemethyl)amino]-~-~ucase (6) in yields >75%. Glycosidation of 6 with different alcohols (MeOH,
C-Glycosyl compounds represent a class of products used as chiral synthons' and as potential glycosidase inhibitors'. A number of methods have been devised for their synthesis3, but despite the biological importance of D-glucosamine, few C-glycosyl derivatives of this carbohydrate have been synthesi