✦ LIBER ✦

Syntheses of di-tritiated 9(O)-methano-Δ6(9α)-prostaglandin I1 methyl esters

✍ Scribed by Kenji Manabe; Toshio Tanaka; Seizi Kurozumi; Yoshinori Kato

Publisher: John Wiley and Sons
Year: 1991
Tongue: French
Weight: 698 KB
Volume: 29
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580291003

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Two di‐tritiated isocarbacyclin [9(O)‐methano‐Δ^6^(9α)‐prostaglandin I~1~] methyl esters 5, 10 were synthesized from (Z)‐olefinic precursors 23, 31 at ω‐side chain by catalytic hydrogenation with tritium gas, respectively. These substances 5, 10 having high specific activities can be used for the pharmacokinetics and metabolism studies of 9(O)‐methano‐Δ^6(9α)^‐prostaglandin I~1~ methyl ester 2 and its (17S)‐17,20‐dimethyl derivatives 7.

📜 SIMILAR VOLUMES

Syntheses of poly-deuterated 9(O)-methan

Syntheses of poly-deuterated 9(O)-methano-Δ6(9α)-prostaglandin I1 methyl esters

✍ Toshio Tanaka; Kiyoshi Bannai; Atsuo Hazato; Kenji Manabe; Seizi Kurozumi 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 French ⚖ 796 KB

Steroids CCCI (1). Radiochemical synthes

Steroids CCCI (1). Radiochemical syntheses. Part I. Preparation of tritiated 6α, 9α-difluoro cortical hormones

✍ D. L. Wren; J. B. Siddall; J. A. Edwards 📂 Article 📅 1967 🏛 John Wiley and Sons 🌐 French ⚖ 473 KB

## A six-step synthesis of tritiated 6a, 9a-d~uoro-l6u-methyl-11~, 17u,21 -trihydroxypregna-l,4-diene-3,20-dione (5) and 6a,9a-di~?uoro-11 f3,16a,I 7aJI -tetrahydroxypregna-I ,4-diene-3,20-dione 16~7-aeetonide ( 7 ) from the appropriate A174?9(11)-3-keto intermediates is described. Isotope inco

A convenient synthesis of β-alkynylpropi

A convenient synthesis of β-alkynylpropionic acids from β-propiolactones. Synthesis of 4,4,5,5-tetradehydro-9(O)-methano-Δ6(9α)-PGI1

✍ Masaki Shinoda; Katsuhiko Iseki; Tomei Oguri; Yosio Hayasi; Shun-ichi Yamada; Ma 📂 Article 📅 1986 🏛 Elsevier Science 🌐 French ⚖ 230 KB

## (O)-methano-A 6(9a)_pGI has been synthesized by utilizing the regiocontrolled cleavage of the B-propio&one tiith the dialkylaluminum acetylide.

Syntheses of (α2–9) and (α2–8) linked di

Syntheses of (α2–9) and (α2–8) linked dineuraminyl saccharides by use of 2β-bromo-3β-hydroxy-4,7,8,9-tetra-o-acetyl-n-acetylneuraminic acid methyl ester1

✍ Kaoru Okamoto; Tadao Kondo; Toshio Goto 📂 Article 📅 1988 🏛 Elsevier Science 🌐 French ⚖ 755 KB

ChemInform Abstract: Five-Membered 2,3-D

ChemInform Abstract: Five-Membered 2,3-Dioxo Heterocycles. Part 66. Reaction of 3-Aroyl-1H-pyrrolo[2,1-][1,4]benzoxazine-1,2,4-triones with α-Enamino Esters. Crystalline and Molecular Structure of Methyl 11-Benzoyl-2-o-hydroxyphenyl-3,4,10-trioxo-6,9-diphenyl-7-oxo-2,9-diazat ricyclo[6.2.1.01,5]undec-5-ene-8-carboxylate.

✍ N. L. Racheva; Z. G. Aliev; A. N. Maslivets 📂 Article 📅 2009 🏛 John Wiley and Sons ⚖ 26 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v