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Syntheses of a New Series of N-Amino-N′-(benzenesulfonyl)guanidine Derivatives with Potential Antitumor Activity.

✍ Scribed by J. Slawinski; P. Bednarski; R. Gruenert; P. Reszka


Publisher
John Wiley and Sons
Year
2003
Weight
147 KB
Volume
34
Category
Article
ISSN
0931-7597

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## Abstract Some derivatives of quinazoline and 1, 2‐dihydroquinazoline __N__^3^‐oxide were synthesised and their cytotoxic activities against human leukaemia HL‐60 cells under hypoxic and aerobic conditions were tested and compared to tirapazamine as the reference compound. Compound 8 showed 5‐fol