Syntheses of 2,2-bishydroxymethylcyclopropyl adenine and uracil, novel carbocyclic nucleosides
โ Scribed by Shigeru Nishiyama; Shinya Ueki; Tatsuya Watanabe; Shosuke Yamamura; Kuniki Kato; Tomohisa Takita
- Book ID
- 104212848
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- French
- Weight
- 135 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0040-4039
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๐ SIMILAR VOLUMES
LNA (Locked Nucleic Acids) is a novel oligonucleotide analogue containing [2.2.1 ]bicycle nucleoside monomers. A novel and significantly improved method for convergent synthesis of LNA [2.2.1]bicycle nucleosides using a 4-Ctosyloxymethyl-l,2-di-O-acetyl furanose as a key synthon is described. In add
(ๅ)-trans-1-[2-(Hydroxymethyl)cyclopentylmethyl]uracil (1) was prepared in two steps and \(56 \%\) yield from 2-hydroxymethylcyclopentylmethylamine (7) and 3-methoxy-2-propenoylisocyanate (6). Isocyanate 6 was prepared from methyl 3-methoxy-2-propenoate in four steps and \(38 \%\) overall yield.