✦ LIBER ✦

Novel convenient syntheses of LNA [2.2.1]bicyclo nucleosides

✍ Scribed by Alexei A. Koshkin; Vivek K. Rajwanshi; Jesper Wengel

Book ID: 104259292
Publisher: Elsevier Science
Year: 1998
Tongue: French
Weight: 213 KB
Volume: 39
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(98)00706-0

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✦ Synopsis

LNA (Locked Nucleic Acids) is a novel oligonucleotide analogue containing [2.2.1 ]bicycle nucleoside monomers. A novel and significantly improved method for convergent synthesis of LNA [2.2.1]bicycle nucleosides using a 4-Ctosyloxymethyl-l,2-di-O-acetyl furanose as a key synthon is described. In addition, an alternative, robust linear approach allowing selective formation of the desired [2.2.1 ]bicycle LNA nueleosides via a tricyclic nucleoside intermediate is introduced.

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