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Syntheses of 1-substituted 1,2,4-triazoles, imidazoles and benzimidazoles

โœ Scribed by Abdollah Sharifian; Kaykavoos Parang; Hassan Zorrieh-Amirian; Mehrdad Nazarinia; Abbas Shafiee

Book ID
112131055
Publisher
Journal of Heterocyclic Chemistry
Year
1994
Tongue
English
Weight
186 KB
Volume
31
Category
Article
ISSN
0022-152X

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Novel tri-substituted 1,2,4-triazoles are synthesized via complementary, regiospecific routes as part of a lead finding exercise. A key feature of one of the syntheses is recognition of an intrinsic regioselectivity toward deprotonation in the 1-phenylguanazole substrate.