Concise and regiospecific syntheses of tri-substituted 1,2,4-triazoles

✍ Scribed by Andrew R Dunstan; Hans-Peter Weber; Grety Rihs; Hans Widmer; Edward K Dziadulewicz

• Book ID: 104260013
• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 180 KB
• Volume: 39
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(98)01736-5

✦ Synopsis

Novel tri-substituted 1,2,4-triazoles are synthesized via complementary, regiospecific routes as part of a lead finding exercise. A key feature of one of the syntheses is recognition of an intrinsic regioselectivity toward deprotonation in the 1-phenylguanazole substrate.