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Syntheses and evaluation of macrocyclic engelhardione analogs as antitubercular and antibacterial agents

โœ Scribed by Shen, Li; M Maddox, Marcus; Adhikari, Sudip; Bruhn, David F; Kumar, Manish; Lee, Robin E; Hurdle, Julian G; Lee, Richard E; Sun, Dianqing

Book ID
121418065
Publisher
Nature Publishing Group
Year
2013
Tongue
English
Weight
425 KB
Volume
66
Category
Article
ISSN
0021-8820

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## Syntheses of New Isodethiaazacephems as Potent Antibacterial Agents. -The syntheses of racemic title compounds (I) and (II) are achieved as described with subsequent deprotection of (IV), (VI), and (VII) to generate azacephems (Ia)-(Ic). In comparison with parent compound (Ia), the antibacteri