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Syntheses and CD studies of optically active substituted 1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-ones

✍ Scribed by Malik, Farnaz ;Hasan, Mashooda ;Khan, Khalid Mohammed ;Perveen, Shahnaz ;Snatzke, Günther ;Duddeck, Helmut ;Voelter, Wolfgang

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
973 KB
Volume
1995
Category
Article
ISSN
0947-3440

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✦ Synopsis

Abstract

A route to optically active variously substituted 4‐methyl‐ and 4‐methyl‐7‐substituted 1,3,4,5‐tetrahydro‐2__H__‐1,5‐benzo‐diazepin‐2‐ones as analogues of commercially available Lofendazam (7‐chloro‐5‐phenyl‐1,3,4,5‐tetrahydro‐2__H__‐1,5‐benzodiazepin‐2‐one, 1) was developed. Fortyone variously substituted optically active compounds having the same configuration were prepared and the UV and CD spectra of the parent compounds bearing no additional substitution in the benzene ring are discussed.

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