Syntheses and Antiviral Activities of Some 5′-O-Acyl Derivatives
✍ Scribed by Klaus Keppeler; Gebhard Kiefer; Erik De Clercq
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 341 KB
- Volume
- 317
- Category
- Article
- ISSN
- 0365-6233
No coin nor oath required. For personal study only.
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5'-O-[N-(Anhacyl w imtxy~yJ)sulfi~noyl]uridines 4a+ 5a-e and 5'4-[N~isopoprl)sulh~yI]~ytibs 7-9 have been 8 -d and testcd againat herpes simplex Virus rype 2. condensation of 2',3'-0-isoproWlide-nv5'4-sulfamoyluridim with the N-hydmxysuccinimide esters of Boc-GIy, Boc-LA4 Boc-D-Ah and Boc-LPhe, gave
## Abstract Starting from 5‐nitro‐2‐furoyl azide **(1)**, some new 5‐nitro‐2‐furamides **2a–d**, __O__‐alkyl __N__‐(5‐nitro‐2‐furyl)carbamates **3a,b** and 5‐nitro‐2‐ureidofurans **4a,b** were synthesized and tested for in vitro antimicrobial activity. Compounds **2c** and **2d** exhibited apprecia