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Synthesen Makrocyclischer Lactone durch Ringerweiterung. Vorläufige Mitteilung

✍ Scribed by Kalina Kostova; Manfred Hesse

Publisher
John Wiley and Sons
Year
1983
Tongue
German
Weight
159 KB
Volume
66
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

Syntheses of Macrocyclic Lactones by Ring Enlargement Reaction

A general method is given for the synthesis of macrocyclic lactones by ring enlargement of 2‐nitrocycloalkanones by four ring members. By this procedure 2‐nitrocyclooctanone (1) is transformed to 8‐oxo‐dodecan‐11‐olid (5) in an overall yield of 63,5% and 2‐nitrocyclododecanone to 12‐oxo‐hexadecan‐15‐olid with 60% yield.

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