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Synthese makrocyclischer Lactone durch Ringerweiterung. Vorläufige Mitteilung

✍ Scribed by Kalina Kostova; Annalaura Lorenzi-Riatsch; Yoshihiko Nakashita; Manfred Hesse

Publisher
John Wiley and Sons
Year
1982
Tongue
German
Weight
143 KB
Volume
65
Category
Article
ISSN
0018-019X

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✦ Synopsis

Synthesis of Macrocyclic Lactones by Ring Enlargement Reaction

Treatment of 3‐(1‐nitro‐2‐oxocyclohexyl)propanal (1) prepared by Michael addition of 2‐nitrocyclohexanon and acrylaldehyde with methyltri (2‐propoxy)tita‐nium yielded a mixture of 2 and 3 which was converted into 6‐nitro‐9‐decanolide (4).

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