Synthese von 5′-Mono-, 5′-Di- und 5′-Triphosphaten der Nucleoside 2.4-Dithio-uridin, 2.4-Dithio-ribothymidin, 2-Thiothymidin und 2.4-Dithio-thymidin

✍ Scribed by Faerber, Peter ;Scheit, Karl Heinz

• Publisher: Wiley (John Wiley & Sons)
• Year: 1971
• Tongue: English
• Weight: 287 KB
• Volume: 104
• Category: Article
• ISSN: 0009-2940
• DOI: 10.1002/cber.19711040214

✦ Synopsis

4

2-Thio-thymidin-5'-phosphat (3), 2.4-Dithio-thymidin-5'4riphosphat (8c), 2.4-Dithio-uridin-5'-diphosphat (7a), 2.4-Dithio-ribothymidin-5'-diphosphat (7b) und 2.4-Dithio-uridin-5'triphosphat (8a) wurden synthetisiert. Als Reinheitskriterien dienen das Verhalten in Papierchromatographie sowie Papierelektrophorese und der Phosphatgehalt.

The Chemical Synthesis of 2.4-Dithiopyrimidine Nucleoside-5'-mono-and -polyphosphates

The synthesis of 2-thiothymidine-5'-phosphate (3), 2.4-dithiothymidine-5'-triphosphate ( 8 ~) .

2.4-dithiouridine-5'-diphosphate (7a), 2.4-dithioribothymidine-S'-diphosphate (7b), and 2.4dithiouridine-5'-triphosphate (8a) is reported. The behaviour in paper chromatography and paper electrophoresis as well as the phosphate content have been used as criteria of the purity.